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eMediNexus 14 December 2022
A prospective, randomized clinical study evaluated the efficacy and tolerability of preoperative pregabalin on cardiovascular response to laryngoscopy and endotracheal intubation.
The study recruited patients aged 18–60 years with an American Society of Anesthesiologists scale score of I or II and randomized them to receive placebo (control), low-dose (150-mg) pregabalin, or high-dose (300-mg) pregabalin. The patients received the oral dose of medications 1 hour before general anesthesia. They were assessed for Heart rate, systolic and diastolic blood pressures, and mean arterial blood pressure before medication, before endotracheal intubation, and at 0, 1, 3, 5, 7, and 10 minutes after intubation. Further, their sedation score was recorded 1 hour after administering the placebo or pregabalin.
The findings of the study were as follows-
Thus this study shows that high-dose (300-mg) pregabalin can effectively attenuate cardiovascular response after endotracheal intubation.
Clinical Therapeutics. 2019;41(1):68-77. https://doi.org/10.1016/j.clinthera.2018.11.006.
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